A New Perspective on Appetite Control: Protein Tyrosine Phosphatase 1b (Ptp1b) Inactivation by Oxidative Phytochemicals
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چکیده
منابع مشابه
A New Perspective on Appetite Control: Protein Tyrosine Phosphatase 1b (Ptp1b) Inactivation by Oxidative Phytochemicals
The leptin signal pathway relies on Janus kinase (JAK) and signal transducer/activator of transcription (STAT) proteins to propagate its signal. When leptin binds to its receptor, JAK2 is activated to phosphorylate leptin receptor and STAT3. The phosphorylated STAT3 dimerize and become capable of modulating gene expression in the nucleus. The JAK/STAT signal is modulated by a negative regulator...
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Protein tyrosine phosphatase 1B (PTP1B) is a validated drug target, but it has proven difficult to develop medicinally useful, reversible inhibitors of this enzyme. Here we explored covalent strategies for the inactivation of PTP1B using a conjugate composed of an active site-directed 5-aryl-1,2,5-thiadiazolidin-3-one 1,1-dioxide inhibitor connected via a short linker to an electrophilic α-brom...
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ژورنال
عنوان ژورنال: Advances in Obesity, Weight Management & Control
سال: 2017
ISSN: 2378-3168
DOI: 10.15406/aowmc.2017.07.00197